Oprah Winfrey will announce on her show Friday that “The Oprah Winfrey Show” will come to an end on Sept. 9, 2011, after 25 years, according to ABC’s Chicago affiliate, KABC.

The announcement would put an end to weeks of speculation that Winfrey may leave daytime syndication and possibly move her show to OWN: The Oprah Winfrey Network, Winfrey’s joint venture with Discovery Communications.

Harpo Prods., which produces the “The Oprah Winfrey Show,” could not be reached for comment Thursday.

“We have the greatest respect for Oprah and wish her nothing but the best in her future endeavors,” the show’s distributor, CBS TV Distribution, said in a statement. “We know that anything she turns her hand to will be a great success. We look forward to working with her for the next several years and hopefully afterwards as well.”